Ara-290 (Cibinetide): A Laboratory Research Reference

Ara-290 (also known as cibinetide) is a synthetic peptide derived from erythropoietin. It is studied in laboratory research for its tissue protective and anti-inflammatory activity, acting independently of the erythropoietin receptor’s erythropoietic effects.

This page is a non-promotional scientific reference for researchers. It summarises the chemical identity, molecular characteristics, mechanism as described in the literature, research areas, and analytical testing of Ara-290. It does not provide dosing, therapeutic, or human-use guidance of any kind. Ara-290 supplied by Bulk Aussie Peptides is for laboratory research purposes only.

What Is Ara-290?

Ara-290 is a synthetic peptide engineered from the erythropoietin molecule to retain its tissue-protective activity while lacking its erythropoietic (red-blood-cell-stimulating) activity. This design separates the two classical roles of erythropoietin — blood-cell production and tissue protection — allowing study of the latter in isolation. It is generally described as acting through an innate-repair-receptor pathway distinct from the classical erythropoietin receptor.

For background on how synthetic research peptides are produced and verified, see the synthetic peptides research guide.

Molecular Characteristics

Several molecular properties are used to identify Ara-290 in analytical documentation:

• Classification: a synthetic, non-erythropoietic peptide derived from erythropoietin.
• Sequence: the exact sequence reproduced in a given study should be read from that study’s methods section.
• Molecular weight: reported in Daltons (Da) on product documentation; the measured value on a Certificate of Analysis should be compared against the theoretical mass derived from the sequence.
• Physical form: supplied as a lyophilised (freeze-dried) powder, the standard presentation for research peptides.

How Ara-290 Works

Ara-290 is described as promoting tissue repair and reducing inflammation through a receptor pathway that is distinct from the classical erythropoietin receptor dimer responsible for red-blood-cell production. This separation is central to its identity as a non-erythropoietic erythropoietin derivative, and it is the basis for studies examining its activity in nerve, wound, and inflammatory models.

These observations are preclinical and describe peptide activity in model systems; they do not constitute a therapeutic use.

Areas of Scientific Research

The research literature describes several lines of investigation involving Ara-290:

• Tissue protection: studies in nerve, wound, and organ-protection models.
• Anti-inflammatory activity: investigation of inflammation-related signalling.
• Non-erythropoietic engineering: work examining the separation of tissue-protective from erythropoietic activity.

These investigations are conducted in vitro or in approved animal research models under institutional oversight. They do not translate to approved human use.

Analytical Testing

As with other research peptides, Ara-290 is characterised using:

• HPLC for purity assessment, reported as a percentage of total peak area.
• Mass spectrometry for identity confirmation, by comparing measured molecular mass to the theoretical value.

Guidance on interpreting the resulting documents is available in the article on how to read a peptide Certificate of Analysis.

Storage and Handling

In a laboratory context, lyophilised Ara-290 is typically stored in a freezer, protected from light and moisture, and handled according to the product-specific documentation. Once reconstituted, the resulting solution is refrigerated and used within the timeframe stated in the documentation. General guidance is covered in the peptide storage and stability reference.

Frequently Asked Questions

• What is Ara-290? Ara-290 (cibinetide) is a synthetic, non-erythropoietic peptide derived from erythropoietin.
• What is cibinetide? Cibinetide is the non-proprietary name for Ara-290.
• Is Ara-290 the same as erythropoietin? No — it is a derived peptide that retains tissue-protective activity without the erythropoietic (red-blood-cell) activity.
• What is Ara-290 studied for? It is investigated in laboratory models for tissue protection and anti-inflammatory activity.
• How is Ara-290 purity tested? Purity is commonly estimated by HPLC, while identity is confirmed by mass spectrometry.

References

• Brines, M., Patel, N. S. A., Villa, P., et al. (2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of the National Academy of Sciences, 105(31), 10925–10930.
• Collino, M., Thiemermann, C., Cerami, A., & Brines, M. (2015). Flipping the molecular switch for innate protection and repair of tissues: long-lasting tissue protection by the erythropoietin-derived peptide pHBSP/Ara290. Expert Opinion on Investigational Drugs.

Related Research Resources

• LL-37: A Laboratory Research Reference — a peptide with immune-modulating activity.
• BPC-157: A Laboratory Research Reference — a related tissue-repair research peptide.
• Synthetic Peptides: Research Guide — how research peptides are produced and verified.