PT-141 (Bremelanotide): A Laboratory Research Reference

PT-141, also known as bremelanotide, is a synthetic peptide in the melanocortin family, engineered from the alpha-melanocyte–stimulating hormone (α-MSH) sequence. It is studied in laboratory research for its activity at melanocortin receptors, which are expressed across a range of tissues and implicated in several physiological signalling pathways.

This page is a non-promotional scientific reference for researchers. It does not provide sexual-health, therapeutic, or human-use guidance. PT-141 supplied by Bulk Aussie Peptides is for laboratory research purposes only.

Chemical Identity

PT-141 is a synthetic peptide derived from the α-MSH sequence, designed to act as a melanocortin receptor agonist. It is structurally related to, but distinct from, the melanocortin peptides MT-1 and MT-2. Its melanocortin activity places it in a class of peptides studied for their signalling through melanocortin receptor subtypes.

As a synthetic peptide, PT-141 is assembled in the laboratory, then purified and characterised before it is supplied for research. For background on production and verification, see the synthetic peptides research guide.

Receptor Pharmacology

In laboratory models, PT-141 engages melanocortin receptors, a family of G-protein–coupled receptors with multiple subtypes expressed across different tissues. The specific subtype profile and downstream effects are the focus of ongoing preclinical investigation. Findings remain research-level and do not constitute a therapeutic claim.

Molecular Characteristics

• Classification: a synthetic melanocortin receptor agonist derived from α-MSH.
• Sequence basis: engineered from the α-melanocyte–stimulating hormone sequence.
• Molecular weight: reported in Daltons (Da) and compared against the theoretical sequence-derived mass.
• Physical form: lyophilised (freeze-dried) powder.

Areas of Scientific Research

• Melanocortin receptor pharmacology: subtype binding and downstream signalling.
• Melanocortin peptide structure: how α-MSH-derived sequences interact with receptor subtypes.
• Signalling pathways: G-protein–coupled signalling downstream of melanocortin receptors.

These investigations are conducted in vitro or in approved animal research models under institutional oversight.

Analytical Testing

PT-141 is characterised using:

• HPLC for purity assessment.
• Mass spectrometry for identity confirmation by molecular mass.

See how to read a peptide Certificate of Analysis for interpretation guidance.

References and Further Reading

• PT-141 and the melanocortin peptide family. (Preclinical research literature on melanocortin receptor agonism.)
• Synthetic Peptides: Research Guide.
• Reading a Peptide Certificate of Analysis.